Anti-B. anthracis protective antigen (PA) Recombinant Antibody (14B7)
CAT#: MRO-073CT
Recombinant monoclonal antibody specifically binds to Bacillus anthracis protective antigen (PA), expressed in Chinese Hamster Ovary cells(CHO).
Published Data
Tested Data
Neut
Figure 1 Neutralization of lethal toxin activity by anti-PA MAbs.
Various concentrations of purified human (1303) and murine (1G3,14B7) MAbs were premixed with anthrax lethal toxin (400 ng PA and40 ng LF per ml) before addition to J774A.1 macrophages. Viability was determined after 3h of incubation. Values represent the means ofresults from duplicate wells of a representative experiment.
Vitale, L., Blanset, D., Lowy, I., O'Neill, T., Goldstein, J., Little, S. F., ... & Keler, T. (2006). Prophylaxis and therapy of inhalational anthrax by a novel monoclonal antibody to protective antigen that mimics vaccine-induced immunity. Infection and immunity, 74(10), 5840-5847.
FC
Figure 2 MAb 1303 does not block PA binding to cells.
Flow cytometryof PA-FITC binding to human monocytes in the presence or absence ofanti-PA antibodies was analyzed. Anti-PA antibodies (14B7, 10 μg/ml;1303, 10 μg/ml) were preincubated with PA-FITC for 20min prior to incubation with monocytes for 1 h at ambient temperature. After washing, the cell-associated fluorescence was determined. The shaded histogram represents cells not exposed to PA-FITC.
Vitale, L., Blanset, D., Lowy, I., O'Neill, T., Goldstein, J., Little, S. F., ... & Keler, T. (2006). Prophylaxis and therapy of inhalational anthrax by a novel monoclonal antibody to protective antigen that mimics vaccine-induced immunity. Infection and immunity, 74(10), 5840-5847.
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SDS-PAGE
Figure 1 Anti-B. anthracis protective antigen (PA) Antibody (MRO-073CT) in SDS-PAGE
Lane 1: Reduced
Lane 2: Non-reduced
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Specifications
- Host Species
- Human
- Type
- Human antibody
- Species Reactivity
- B. anthracis
- Clone
- 14B7
- Applications
- Neut, FC
- Related Disease
- Anthrax (Bacillus anthracis)
Applications
- Application Notes
- This antibody has been reported for use in Neutralization and Flow Cytometry.
Target
- Alternative Names
- PA; PA83; pag; PagA; Protective antigen; Bacillus anthracis; B. anthracis
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-099 | Mouse Anti-PA Recombinant Antibody (clone 14B7*) | Neut | Mouse IgG |
| PABZ-099 | Mouse Anti-PA Recombinant Antibody (clone 1H) | Neut | Mouse IgG |
| PABW-099 | Mouse Anti-PA Recombinant Antibody (clone M18) | Neut | Mouse IgG |
| HPAB-J0202-YC | Mouse Anti-PA Recombinant Antibody (HPAB-J0202-YC) | ELISA, Neut | Mouse IgG |
| HPAB-J0203-YC | Mouse Anti-PA Recombinant Antibody (HPAB-J0203-YC) | ELISA, Neut | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-099 | Mouse Anti-PA Recombinant Antibody (clone 14B7*); Fab Fragment | Neut | Mouse Fab |
| PFBZ-099 | Mouse Anti-PA Recombinant Antibody (clone 1H); Fab Fragment | Neut | Mouse IgG |
| PFBW-099 | Mouse Anti-PA Recombinant Antibody (clone M18); Fab Fragment | Neut | Mouse Fab |
| HPAB-J0202-YC-F(E) | Mouse Anti-PA Recombinant Antibody; Fab Fragment (HPAB-J0202-YC-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-J0203-YC-F(E) | Mouse Anti-PA Recombinant Antibody; Fab Fragment (HPAB-J0203-YC-F(E)) | ELISA, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-099 | Mouse Anti-PA Recombinant Antibody (clone 14B7*); scFv Fragment | Neut | Mouse scFv |
| PSBZ-099 | Mouse Anti-PA Recombinant Antibody (clone 1H); scFv Fragment | Neut | Mouse scFv |
| PSBW-099 | Mouse Anti-PA Recombinant Antibody (clone M18); scFv Fragment | Neut | Mouse scFv |
| HPAB-J0202-YC-S(P) | Mouse Anti-PA Recombinant Antibody; scFv Fragment (HPAB-J0202-YC-S(P)) | ELISA, Neut | Mouse scFv |
| HPAB-J0203-YC-S(P) | Mouse Anti-PA Recombinant Antibody; scFv Fragment (HPAB-J0203-YC-S(P)) | ELISA, Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-059CT-S(P) | Anti-B. anthracis protective antigen Recombinant Antibody scFv Fragment (MRO-059CT-S(P)) | ELISA, WB | Human antibody |
| MRO-060CT-S(P) | Anti-B. anthracis protective antigen Recombinant Antibody scFv Fragment (MRO-060CT-S(P)) | ELISA, WB | Human antibody |
| MRO-061CT-S(P) | Anti-B. anthracis protective antigen Recombinant Antibody scFv Fragment (MRO-061CT-S(P)) | ELISA, WB | Human antibody |
| MRO-062CT-S(P) | Anti-B. anthracis protective antigen Recombinant Antibody scFv Fragment (MRO-062CT-S(P)) | ELISA, WB | Human antibody |
| MRO-063CT-S(P) | Anti-B. anthracis protective antigen Recombinant Antibody scFv Fragment (2A6) | ELISA, Neut | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-440CQ | Anti-Bacillus Anthracis PA Recombinant Antibody (TAB-440CQ) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF670 | H-2Db/Influenza A Polymerase acidic protein (SSLENFRAYV) MHC Pentamer | FCM | |
| MHC-YF671 | H-2Db/Influenza A Polymerease PA (SCLENFRAYV) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY67 | Human Anti-PA scFv-Fc Chimera (VS-0425-FY67) | WB, ELISA | Human IgG1, scFv-Fc |
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